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Assessment of primary hemostasis by PFA-100 analysis in a tertiary care center.

Publication ,  Journal Article
Ortel, TL; James, AH; Thames, EH; Moore, KD; Greenberg, CS
Published in: Thromb Haemost
July 2000

We evaluated the utility of the PFA-100 platelet function analyzer in identifying disorders in platelet function and/or von Willebrand factor (vWF) in patients with various systemic disorders being followed at a tertiary care center. Closure times were determined with collagen/ ADP (CADP) and collagen/epinephrine (CEPI) cartridges for 305 patients, and abnormal results were further evaluated with platelet aggregometry and vWF analysis. Prolonged CADP and/or CEPI closure times were identified in 114 patients (37.3%), but most were isolated prolonged CEPI closure times predominantly due to aspirin therapy (79 patients). Prolonged CADP closure times were most frequently due to qualitative platelet defects and/or decreased vWF levels. Prolonged CADP closure times were encountered most frequently in patients with sickle cell disease and were associated with a decreased hematocrit. This study demonstrated that the PFA-100 analyzer can accurately assess vWF-dependent platelet function and detect other platelet defects under high shear stress in complex patient populations.

Duke Scholars

Published In

Thromb Haemost

ISSN

0340-6245

Publication Date

July 2000

Volume

84

Issue

1

Start / End Page

93 / 97

Location

Germany

Related Subject Headings

  • von Willebrand Diseases
  • Time Factors
  • Stress, Mechanical
  • Pregnancy
  • Platelet Function Tests
  • Platelet Aggregation
  • Platelet Activation
  • Outpatient Clinics, Hospital
  • North Carolina
  • Middle Aged
 

Citation

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ICMJE
MLA
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Ortel, T. L., James, A. H., Thames, E. H., Moore, K. D., & Greenberg, C. S. (2000). Assessment of primary hemostasis by PFA-100 analysis in a tertiary care center. Thromb Haemost, 84(1), 93–97.
Ortel, T. L., A. H. James, E. H. Thames, K. D. Moore, and C. S. Greenberg. “Assessment of primary hemostasis by PFA-100 analysis in a tertiary care center.Thromb Haemost 84, no. 1 (July 2000): 93–97.
Ortel TL, James AH, Thames EH, Moore KD, Greenberg CS. Assessment of primary hemostasis by PFA-100 analysis in a tertiary care center. Thromb Haemost. 2000 Jul;84(1):93–7.
Ortel, T. L., et al. “Assessment of primary hemostasis by PFA-100 analysis in a tertiary care center.Thromb Haemost, vol. 84, no. 1, July 2000, pp. 93–97.
Ortel TL, James AH, Thames EH, Moore KD, Greenberg CS. Assessment of primary hemostasis by PFA-100 analysis in a tertiary care center. Thromb Haemost. 2000 Jul;84(1):93–97.
Journal cover image

Published In

Thromb Haemost

ISSN

0340-6245

Publication Date

July 2000

Volume

84

Issue

1

Start / End Page

93 / 97

Location

Germany

Related Subject Headings

  • von Willebrand Diseases
  • Time Factors
  • Stress, Mechanical
  • Pregnancy
  • Platelet Function Tests
  • Platelet Aggregation
  • Platelet Activation
  • Outpatient Clinics, Hospital
  • North Carolina
  • Middle Aged