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Abnormal optical waveform profiles in coagulation assays from patients with antiphospholipid antibodies.

Publication ,  Journal Article
Su, Z; Braun, PJ; Klemp, KF; Baker, KR; Thames, EH; Ortel, TL
Published in: Blood Coagul Fibrinolysis
January 2002

Transmittance waveforms are the optical data generated during clot formation on photo-optical coagulation analyzers and are used to define specific events of the clotting reactions. Thus, a prothrombin time (PT) or an activated partial thromboplastin time (aPTT) can be divided into a pre-coagulation phase, a coagulation phase, and a post-coagulation phase. These phases are further characterized by parameters that define the timing, the rate, the 'slope', and the magnitude of the signal change of the reactions. We investigated the transmittance waveform parameters obtained during PT and aPTT of patients with antiphospholipid antibodies (APLA) who were or were not taking warfarin, normal donors, and non-APLA patients taking warfarin. An abnormal deflection in the pre-coagulation phase of the PT (called slope 1) was observed in 61.5% of the patients with APLA, in contrast to 5.9% of non-APLA patients taking warfarin (P= 0.0015). The presence of an abnormal PT slope 1 was reagent specific and was inversely correlated with the anticardiolipin antibody immunoglobulin G (IgG) level, which suggests that the abnormal PT slope 1 may reflect interactions between patient IgG and components from the thromboplastin, possibly phospholipids. The abnormal PT slope 1 values may be of diagnostic utility in the identification of patients with antiphospholipid syndromes.

Duke Scholars

Published In

Blood Coagul Fibrinolysis

DOI

ISSN

0957-5235

Publication Date

January 2002

Volume

13

Issue

1

Start / End Page

7 / 17

Location

England

Related Subject Headings

  • Warfarin
  • Kinetics
  • Indicators and Reagents
  • Humans
  • Case-Control Studies
  • Cardiovascular System & Hematology
  • Blood Coagulation Tests
  • Antiphospholipid Syndrome
  • Anticoagulants
  • Antibodies, Antiphospholipid
 

Citation

APA
Chicago
ICMJE
MLA
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Su, Z., Braun, P. J., Klemp, K. F., Baker, K. R., Thames, E. H., & Ortel, T. L. (2002). Abnormal optical waveform profiles in coagulation assays from patients with antiphospholipid antibodies. Blood Coagul Fibrinolysis, 13(1), 7–17. https://doi.org/10.1097/00001721-200201000-00002
Su, Z., P. J. Braun, K. F. Klemp, K. R. Baker, E. H. Thames, and T. L. Ortel. “Abnormal optical waveform profiles in coagulation assays from patients with antiphospholipid antibodies.Blood Coagul Fibrinolysis 13, no. 1 (January 2002): 7–17. https://doi.org/10.1097/00001721-200201000-00002.
Su Z, Braun PJ, Klemp KF, Baker KR, Thames EH, Ortel TL. Abnormal optical waveform profiles in coagulation assays from patients with antiphospholipid antibodies. Blood Coagul Fibrinolysis. 2002 Jan;13(1):7–17.
Su, Z., et al. “Abnormal optical waveform profiles in coagulation assays from patients with antiphospholipid antibodies.Blood Coagul Fibrinolysis, vol. 13, no. 1, Jan. 2002, pp. 7–17. Pubmed, doi:10.1097/00001721-200201000-00002.
Su Z, Braun PJ, Klemp KF, Baker KR, Thames EH, Ortel TL. Abnormal optical waveform profiles in coagulation assays from patients with antiphospholipid antibodies. Blood Coagul Fibrinolysis. 2002 Jan;13(1):7–17.

Published In

Blood Coagul Fibrinolysis

DOI

ISSN

0957-5235

Publication Date

January 2002

Volume

13

Issue

1

Start / End Page

7 / 17

Location

England

Related Subject Headings

  • Warfarin
  • Kinetics
  • Indicators and Reagents
  • Humans
  • Case-Control Studies
  • Cardiovascular System & Hematology
  • Blood Coagulation Tests
  • Antiphospholipid Syndrome
  • Anticoagulants
  • Antibodies, Antiphospholipid