Frequency of anti-heparin-platelet factor 4 antibodies in hemodialysis patients and correlation with recurrent vascular access thrombosis.
Published
Journal Article
Heparin-induced thrombocytopenia (HIT), characterized by the formation of antibodies to a complex of platelet factor 4 (PF4) and heparin, is a well-recognized risk factor for thromboembolic complications. The frequency of antibody development varies among patient populations. Hemodialysis patients have repeated heparin exposure and should be at risk of developing HIT. This might, contribute to the development of vascular access thrombosis. We prospectively evaluated 88 hemodialysis patients for the presence of anti-PF4/heparin antibodies. Eighteen patients (20%) had a prior history of 1 or more prior access thrombosis. One patient (1.14%), without a history of graft thrombosis, tested positive for anti-PF4/heparin antibodies. In our study, the presence of anti-PF4/heparin antibodies was rare and was not increased in patients with a history of vascular access thrombosis.
Full Text
Duke Authors
Cited Authors
- O'Shea, SI; Sands, JJ; Nudo, SA; Ortel, TL
Published Date
- January 2002
Published In
Volume / Issue
- 69 / 1
Start / End Page
- 72 - 73
PubMed ID
- 11835336
Pubmed Central ID
- 11835336
International Standard Serial Number (ISSN)
- 0361-8609
Digital Object Identifier (DOI)
- 10.1002/ajh.10032
Language
- eng
Conference Location
- United States