Hematologic disorders and nonimmune hydrops fetalis.

Journal Article (Journal Article;Review)

Hematologic disorders are implicated in approximately 10% to 27% of cases of nonimmune hydrops fetalis. In almost all of these disorders, anemia leading to heart failure, edema, ascites, and anasarca is the final common denominator. The etiology of the anemia in these cases can be conveniently divided into two categories: (1) excessive erythrocyte loss by hemolysis or hemorrhage, and (2) erythrocyte underproduction. The former include intrinsic erythrocyte abnormalities such as alpha-thalassemia and glucose-6-phosphate dehydrogenase deficiency, and conditions with excessive fetal blood loss such as fetomaternal hemorrhage and twin-twin transfusion. The latter include bone marrow replacement syndromes and conditions associated with failure of erythrocyte production. The presentation, diagnosis, and management of hematologic disorders associated with nonimmune hydrops fetalis are reviewed.

Full Text

Duke Authors

Cited Authors

  • Arcasoy, MO; Gallagher, PG

Published Date

  • December 1995

Published In

Volume / Issue

  • 19 / 6

Start / End Page

  • 502 - 515

PubMed ID

  • 8822334

International Standard Serial Number (ISSN)

  • 0146-0005

Digital Object Identifier (DOI)

  • 10.1016/s0146-0005(05)80057-6


  • eng

Conference Location

  • United States