Treatment-mediated changes in human immunodeficiency virus (HIV) type 1 RNA and CD4 cell counts as predictors of weight growth failure, cognitive decline, and survival in HIV-infected children.

Published

Journal Article

This meta-analysis of 5 large studies of the Pediatric AIDS Clinical Trials Group was undertaken to evaluate the predictive value of antiretroviral treatment-mediated changes in 3 markers of human immunodeficiency virus (HIV) type 1 disease progression-HIV-1 RNA level, CD4 cell count, and CD4 percentage-for weight growth failure, cognitive decline, and survival in HIV-infected children. Proportional hazards models were used to assess the prognostic value of the markers at baseline and after 24 weeks of treatment, with data from 1089 children. Among children receiving nucleoside with or without nonnucleoside reverse-transcriptase inhibitors, higher immunologic and lower virologic markers at baseline and after 24 weeks were significant independent predictors of survival, whereas virologic markers were significant predictors of weight growth and cognitive failure in children >1 year old. The finding of differential age effects on pediatric-specific clinical outcomes emphasizes the need for continued investigation of treatment effects in children.

Full Text

Duke Authors

Cited Authors

  • Lindsey, JC; Hughes, MD; McKinney, RE; Cowles, MK; Englund, JA; Baker, CJ; Burchett, SK; Kline, MW; Kovacs, A; Moye, J

Published Date

  • November 2000

Published In

Volume / Issue

  • 182 / 5

Start / End Page

  • 1385 - 1393

PubMed ID

  • 11010839

Pubmed Central ID

  • 11010839

International Standard Serial Number (ISSN)

  • 0022-1899

Digital Object Identifier (DOI)

  • 10.1086/315865

Language

  • eng

Conference Location

  • United States