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Growth, survival and viral load in symptomatic childhood human immunodeficiency virus infection.

Publication ,  Journal Article
Chantry, CJ; Byrd, RS; Englund, JA; Baker, CJ; McKinney, RE; Pediatric AIDS Clinical Trials Group Protocol 152 Study Team,
Published in: Pediatr Infect Dis J
December 2003

BACKGROUND: The relationships among weight and height growth, viral load and survival in HIV-infected children remain unclear. OBJECTIVES: To determine whether weight or height growth velocity independently predicts survival and to investigate associations of weight, height and head circumference growth velocities with viral loads in symptomatic HIV-infected children. METHODS: We analyzed data from a prospective antiretroviral study utilizing clinical endpoints (PACTG 152). Viral load [log(RNA PCR)] and anthropometric measures 12 weeks before and after viral load measures were available in 494 of 831 children. Interval changes during 24 weeks in z-scores for weight-for-age (DeltaWAZ), height-for-age (DeltaHAZ) and head circumference-for-age (DeltaHCZ) were used as growth velocity surrogates. Logistic regression determined whether DeltaWAZ and/or DeltaHAZ correlated with survival when age, viral load and CD4+ cell count were controlled. Bivariate analysis assessed correlation among viral load and DeltaWAZ, DeltaHAZ and/or DeltaHCZ. RESULTS: Survival related significantly to height growth velocity (P = 0.03, n = 434) but not to weight growth velocity (P = 0.84, n = 446) or head circumference growth velocity (P = 0.67, n = 148). Viral load was not significantly associated with changes in weight-, height-, or head circumference-for-age z scores (P = 0.86, n = 235; P = 0.07, n = 226; and P = 0.09, n = 165, respectively) in children <30 months of age or with changes in weight- or height-for-age z scores (P = 0.27, n = 259; P = 0.11, n = 251) in older children. CONCLUSIONS: Height growth velocity predicted survival independently of age, viral load and CD4+ cell count. Weight, height and head circumference growth velocities were not significantly associated with viral load in symptomatic HIV-infected children in this large prospective trial of nucleoside reverse transcriptase therapy.

Duke Scholars

Published In

Pediatr Infect Dis J

DOI

ISSN

0891-3668

Publication Date

December 2003

Volume

22

Issue

12

Start / End Page

1033 / 1039

Location

United States

Related Subject Headings

  • Viral Load
  • United States
  • Survival Rate
  • Sex Distribution
  • Severity of Illness Index
  • Risk Factors
  • RNA, Viral
  • Probability
  • Predictive Value of Tests
  • Polymerase Chain Reaction
 

Citation

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Chantry, C. J., Byrd, R. S., Englund, J. A., Baker, C. J., McKinney, R. E., & Pediatric AIDS Clinical Trials Group Protocol 152 Study Team, . (2003). Growth, survival and viral load in symptomatic childhood human immunodeficiency virus infection. Pediatr Infect Dis J, 22(12), 1033–1039. https://doi.org/10.1097/01.inf.0000100575.64298.bc
Chantry, Caroline J., Robert S. Byrd, Janet A. Englund, Carol J. Baker, Ross E. McKinney, and Ross E. Pediatric AIDS Clinical Trials Group Protocol 152 Study Team. “Growth, survival and viral load in symptomatic childhood human immunodeficiency virus infection.Pediatr Infect Dis J 22, no. 12 (December 2003): 1033–39. https://doi.org/10.1097/01.inf.0000100575.64298.bc.
Chantry CJ, Byrd RS, Englund JA, Baker CJ, McKinney RE, Pediatric AIDS Clinical Trials Group Protocol 152 Study Team. Growth, survival and viral load in symptomatic childhood human immunodeficiency virus infection. Pediatr Infect Dis J. 2003 Dec;22(12):1033–9.
Chantry, Caroline J., et al. “Growth, survival and viral load in symptomatic childhood human immunodeficiency virus infection.Pediatr Infect Dis J, vol. 22, no. 12, Dec. 2003, pp. 1033–39. Pubmed, doi:10.1097/01.inf.0000100575.64298.bc.
Chantry CJ, Byrd RS, Englund JA, Baker CJ, McKinney RE, Pediatric AIDS Clinical Trials Group Protocol 152 Study Team. Growth, survival and viral load in symptomatic childhood human immunodeficiency virus infection. Pediatr Infect Dis J. 2003 Dec;22(12):1033–1039.

Published In

Pediatr Infect Dis J

DOI

ISSN

0891-3668

Publication Date

December 2003

Volume

22

Issue

12

Start / End Page

1033 / 1039

Location

United States

Related Subject Headings

  • Viral Load
  • United States
  • Survival Rate
  • Sex Distribution
  • Severity of Illness Index
  • Risk Factors
  • RNA, Viral
  • Probability
  • Predictive Value of Tests
  • Polymerase Chain Reaction