Three-dimensional MRI microscopy of the normal rat brain.

Journal Article (Journal Article)

Magnetic resonance imaging techniques have been developed to enable imaging of the live rat brain with thin (1.2-mm) slices and microscopic pixels (115 X 115 microns). Signal-to-noise ratios high enough to realize the microscopic resolution are obtained with rf coils designed for the subject and through the use of three-dimensional Fourier spin warp imaging. The technique yields 16 contiguous slices. Correlation with fixed pathologic specimens enables unequivocal identification of gray and white matter structures in the brain of a live 200-g rat. Structures clearly visible in the MR images include Ammon's horn, the hypothalamus, corpus callosum and substantia nigra, as well as a number of brainstem nuclei.

Full Text

Duke Authors

Cited Authors

  • Johnson, GA; Thompson, MB; Drayer, BP

Published Date

  • April 1, 1987

Published In

Volume / Issue

  • 4 / 4

Start / End Page

  • 351 - 365

PubMed ID

  • 3586982

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.1910040406


  • eng

Conference Location

  • United States