Severe chronic graft-versus-host disease is characterized by a preponderance of CD4(+) effector memory cells relative to central memory cells.

Published

Journal Article

Donor alloreactive CD4(+) T cells are important to the pathogenesis of chronic graft-versus-host disease (cGVHD), but specific subsets of CD4(+) T cells responsible for GVHD have not been defined. We hypothesized that cGVHD might be associated with a preponderance of CD4(+) effector memory cells (CCR7(-)/CD62L(low), CD4(EM)). We analyzed CCR7 and CD62L expression on CD4(+) T cells from stem cell transplantation patients, who did or did not develop cGVHD, and healthy donors. Patients with cGVHD had a higher percentage of CD4(EM) cells (35.5% +/- 2.9%) than healthy donors (13.8% +/- 0.7%; P <.0001) or patients without cGVHD that received a transplant (21.7% +/- 2.1%; P <.01). Using corticosteroid dose as a surrogate marker for cGVHD severity, severe cGVHD was associated with a higher percentage of CD4(EM) cells. The proportion of CD4(EM) cells in corticosteroid-dependent patients with systemic lupus erythematosis or Wegener granulomatosis did not differ from patients without cGVHD that received a transplant. This finding implies that overrepresentation of CD4(EM) cells is a unique feature of cGVHD.

Full Text

Duke Authors

Cited Authors

  • Yamashita, K; Choi, U; Woltz, PC; Foster, SF; Sneller, MC; Hakim, FT; Fowler, DH; Bishop, MR; Pavletic, SZ; Tamari, M; Castro, K; Barrett, AJ; Childs, RW; Illei, GG; Leitman, SF; Malech, HL; Horwitz, ME

Published Date

  • May 2004

Published In

Volume / Issue

  • 103 / 10

Start / End Page

  • 3986 - 3988

PubMed ID

  • 14764530

Pubmed Central ID

  • 14764530

Electronic International Standard Serial Number (EISSN)

  • 1528-0020

International Standard Serial Number (ISSN)

  • 0006-4971

Digital Object Identifier (DOI)

  • 10.1182/blood-2003-09-3286

Language

  • eng