Characteristics of chronic left ventricular hypertrophy induced by subcoronary valvular aortic stenosis. I. Myocardial blood flow and metabolism.


Journal Article

Using a canine model of subcoronary valvular aortic stenosis, we determined myocardial blood flow, high-energy phosphate content, and mitochondrial function in eight hearts with chronic left ventricular hypertrophy. Fourteen normal hearts were used for control data. Myocardial blood flow was determined by injection of tracer microspheres. During cardiopulmonary bypass, left ventricular transmural biopsy specimens were taken for metabolic analyses. Subepicardial and subendocardial content of adenosine triphosphate (ATP) and creatine phosphate (CP) were assayed. Respiratory control indices for isolated mitochondria were measured by use of NAD-linked and FAD-linked substrates. Endocardial blood flow, subendocardial high-energy phosphate content, and respiratory control indices for NAD-linked substrate in the hearts with chronic left ventricular hypertrophy were significantly lower than the normal values. These data provide insight into the metabolic and myocardial blood flow abnormalities occurring in cardiac hypertrophy and provide a framework for understanding the altered response of hypertrophied hearts to ischemia.

Full Text

Duke Authors

Cited Authors

  • Attarian, DE; Jones, RN; Currie, WD; Hill, RC; Sink, JD; Olsen, CO; Chitwood, WR; Wechsler, AS

Published Date

  • March 1, 1981

Published In

Volume / Issue

  • 81 / 3

Start / End Page

  • 382 - 388

PubMed ID

  • 6450857

Pubmed Central ID

  • 6450857

International Standard Serial Number (ISSN)

  • 0022-5223


  • eng

Conference Location

  • United States