Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.
Journal Article (Journal Article)
Effects of the cytokine TGF-beta can be dampened by E3 ubiquitin ligases that target specific Smads, the TGF-beta signal transducers, for proteolytic destruction. Two papers in this issue of Cell highlight the importance of this mechanism in regulating the in vivo effects of TGF-beta. The first paper identifies and characterizes a novel Smad4 ubiquitin ligase, and the second paper redefines the role of a previously identified Smad1 ubiquitin ligase, Smurf-1 (Dupont et al., 2005; Yamashita et al., 2005).
Full Text
Duke Authors
Cited Authors
- Datto, M; Wang, X-F
Published Date
- April 8, 2005
Published In
Volume / Issue
- 121 / 1
Start / End Page
- 2 - 4
PubMed ID
- 15820671
International Standard Serial Number (ISSN)
- 0092-8674
Digital Object Identifier (DOI)
- 10.1016/j.cell.2005.03.017
Language
- eng
Conference Location
- United States