Ubiquitin-mediated degradation a mechanism for fine-tuning TGF-beta signaling.

Journal Article (Journal Article)

Effects of the cytokine TGF-beta can be dampened by E3 ubiquitin ligases that target specific Smads, the TGF-beta signal transducers, for proteolytic destruction. Two papers in this issue of Cell highlight the importance of this mechanism in regulating the in vivo effects of TGF-beta. The first paper identifies and characterizes a novel Smad4 ubiquitin ligase, and the second paper redefines the role of a previously identified Smad1 ubiquitin ligase, Smurf-1 (Dupont et al., 2005; Yamashita et al., 2005).

Full Text

Duke Authors

Cited Authors

  • Datto, M; Wang, X-F

Published Date

  • April 8, 2005

Published In

Volume / Issue

  • 121 / 1

Start / End Page

  • 2 - 4

PubMed ID

  • 15820671

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2005.03.017


  • eng

Conference Location

  • United States