Wnt signaling regulates B lymphocyte proliferation through a LEF-1 dependent mechanism.

Published

Journal Article

Lymphocyte enhancer factor-1 (LEF-1) is a member of the LEF-1/TCF family of transcription factors, which have been implicated in Wnt signaling and tumorigenesis. LEF-1 was originally identified in pre-B and T cells, but its function in B lymphocyte development remains unknown. Here we report that LEF-1-deficient mice exhibit defects in pro-B cell proliferation and survival in vitro and in vivo. We further show that Lef1-/- pro-B cells display elevated levels of fas and c-myc transcription, providing a potential mechanism for their increased sensitivity to apoptosis. Finally, we establish a link between Wnt signaling and normal B cell development by demonstrating that Wnt proteins are mitogenic for pro-B cells and that this effect is mediated by LEF-1.

Full Text

Cited Authors

  • Reya, T; O'Riordan, M; Okamura, R; Devaney, E; Willert, K; Nusse, R; Grosschedl, R

Published Date

  • July 2000

Published In

Volume / Issue

  • 13 / 1

Start / End Page

  • 15 - 24

PubMed ID

  • 10933391

Pubmed Central ID

  • 10933391

Electronic International Standard Serial Number (EISSN)

  • 1097-4180

International Standard Serial Number (ISSN)

  • 1074-7613

Digital Object Identifier (DOI)

  • 10.1016/s1074-7613(00)00004-2

Language

  • eng