Interpreting measures of treatment effect in cancer clinical trials.


Journal Article

The efficacy of a new cancer regimen is usually assessed by analyzing outcomes such as tumor response and overall survival. Many publications summarizing results of cancer clinical trials report measures such as odds ratios and hazard ratios, as these are the estimators of treatment effect obtained from regression models used to analyze the data. However, these measures are sometimes misinterpreted, as they are not necessarily familiar to many readers. The most common mistake is to interpret both measures as relative risks, an interpretation that can lead to an incorrect impression of the impact of the treatment on response and survival.

Full Text

Duke Authors

Cited Authors

  • Case, LD; Kimmick, G; Paskett, ED; Lohman, K; Tucker, R

Published Date

  • 2002

Published In

Volume / Issue

  • 7 / 3

Start / End Page

  • 181 - 187

PubMed ID

  • 12065789

Pubmed Central ID

  • 12065789

International Standard Serial Number (ISSN)

  • 1083-7159

Digital Object Identifier (DOI)

  • 10.1634/theoncologist.7-3-181


  • eng

Conference Location

  • United States