Genomic structure of the EPHA1 receptor tyrosine kinase gene.

Journal Article (Journal Article)

Some receptor tyrosine kinase genes are mutated in inherited and somatically acquired human cancers. To permit mutational analysis, the complete genomic structure of the human EPHA1 gene on chromosome 7q34 was determined and oligonucleotide pairs were designed to amplify coding regions. The gene contains 18 exons, two more than the related tyrosine kinase, EPHB2. Presumed sequencing errors in the published cDNA sequence of EPHA1 were identified in exons 10 and 11. Availability of this information will facilitate mutational analysis of EPHA1.

Full Text

Duke Authors

Cited Authors

  • Owshalimpur, D; Kelley, MJ

Published Date

  • June 1999

Published In

Volume / Issue

  • 13 / 3

Start / End Page

  • 169 - 173

PubMed ID

  • 10369740

International Standard Serial Number (ISSN)

  • 0890-8508

Digital Object Identifier (DOI)

  • 10.1006/mcpr.1999.0228


  • eng

Conference Location

  • England