Homodimerization and intermolecular tyrosine phosphorylation of the Tyk-2 tyrosine kinase.

Journal Article (Journal Article)

The Jak kinases and Stat transcription factors play a major role in signaling of various cytokines including IFN alpha. In this report we show a ligand-independent interaction between Tyk-2 and Jak-1 kinases. We also demonstrate that the Tyk-2 kinase forms a homodimer that has the ability to undergo intermolecular tyrosine phosphorylation. The formation of the Tyk-2 homodimer is independent of both tyrosine phosphorylation and the presence of the tyrosine kinase domain.

Full Text

Duke Authors

Cited Authors

  • Domanski, P; Yan, H; Witte, MM; Krolewski, J; Colamonici, OR

Published Date

  • November 6, 1995

Published In

Volume / Issue

  • 374 / 3

Start / End Page

  • 317 - 322

PubMed ID

  • 7589562

International Standard Serial Number (ISSN)

  • 0014-5793

Digital Object Identifier (DOI)

  • 10.1016/0014-5793(95)01094-u


  • eng

Conference Location

  • England