Small changes in expression affect predisposition to tumorigenesis.

Journal Article (Journal Article)

We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.

Full Text

Duke Authors

Cited Authors

  • Yan, H; Dobbie, Z; Gruber, SB; Markowitz, S; Romans, K; Giardiello, FM; Kinzler, KW; Vogelstein, B

Published Date

  • January 2002

Published In

Volume / Issue

  • 30 / 1

Start / End Page

  • 25 - 26

PubMed ID

  • 11743581

International Standard Serial Number (ISSN)

  • 1061-4036

Digital Object Identifier (DOI)

  • 10.1038/ng799


  • eng

Conference Location

  • United States