FOS-1 promotes basement-membrane removal during anchor-cell invasion in C. elegans.

Published

Journal Article

Cell invasion through basement membranes is crucial during morphogenesis and cancer metastasis. Here, we genetically dissect this process during anchor-cell invasion into the vulval epithelium in C. elegans. We have identified the fos transcription factor ortholog fos-1 as a critical regulator of basement-membrane removal. In fos-1 mutants, the gonadal anchor cell extends cellular processes normally toward vulval cells, but these processes fail to remove the basement membranes separating the gonad from the vulval epithelium. fos-1 is expressed in the anchor cell and controls invasion cell autonomously. We have identified ZMP-1, a membrane-type matrix metalloproteinase, CDH-3, a Fat-like protocadherin, and hemicentin, a fibulin family extracellular matrix protein, as transcriptional targets of FOS-1 that promote invasion. These results reveal a key genetic network that controls basement-membrane removal during cell invasion.

Full Text

Duke Authors

Cited Authors

  • Sherwood, DR; Butler, JA; Kramer, JM; Sternberg, PW

Published Date

  • June 2005

Published In

Volume / Issue

  • 121 / 6

Start / End Page

  • 951 - 962

PubMed ID

  • 15960981

Pubmed Central ID

  • 15960981

Electronic International Standard Serial Number (EISSN)

  • 1097-4172

International Standard Serial Number (ISSN)

  • 0092-8674

Digital Object Identifier (DOI)

  • 10.1016/j.cell.2005.03.031

Language

  • eng