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Anchor cell invasion into the vulval epithelium in C. elegans.

Publication ,  Journal Article
Sherwood, DR; Sternberg, PW
Published in: Developmental cell
July 2003

An understanding of cell-invasive behavior has been limited by the lack of in vivo models where this activity can be clearly visualized and manipulated. We show that a single cell in the Caenorhabditis elegans gonad, the anchor cell (AC), initiates uterine-vulval contact through a cell invasion event. Using genetic analysis, laser ablations, and cell-specific markers, we demonstrate that AC invasion is predominantly stimulated by the 1 degrees vulval lineage cells, which generate a diffusible signal that promotes AC invasive behavior toward these cells and further targets invasive processes between the two central 1 degrees vulval lineage cells. We also show that AC invasion is regulated by the AC response to this cue, as well as a vulval-independent mechanism that weakly drives invasion. These studies dissect the regulatory mechanisms that underlie a simple cell-invasive behavior in vivo, and introduce AC invasion as a model for understanding key checkpoints controlling cell invasion.

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Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

July 2003

Volume

5

Issue

1

Start / End Page

21 / 31

Related Subject Headings

  • Vulva
  • Uterus
  • Transgenes
  • Signal Transduction
  • Mutation
  • Luminescent Proteins
  • Green Fluorescent Proteins
  • Gonads
  • Gene Expression Regulation, Developmental
  • Female
 

Citation

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Sherwood, D. R., & Sternberg, P. W. (2003). Anchor cell invasion into the vulval epithelium in C. elegans. Developmental Cell, 5(1), 21–31. https://doi.org/10.1016/s1534-5807(03)00168-0
Sherwood, David R., and Paul W. Sternberg. “Anchor cell invasion into the vulval epithelium in C. elegans.Developmental Cell 5, no. 1 (July 2003): 21–31. https://doi.org/10.1016/s1534-5807(03)00168-0.
Sherwood DR, Sternberg PW. Anchor cell invasion into the vulval epithelium in C. elegans. Developmental cell. 2003 Jul;5(1):21–31.
Sherwood, David R., and Paul W. Sternberg. “Anchor cell invasion into the vulval epithelium in C. elegans.Developmental Cell, vol. 5, no. 1, July 2003, pp. 21–31. Epmc, doi:10.1016/s1534-5807(03)00168-0.
Sherwood DR, Sternberg PW. Anchor cell invasion into the vulval epithelium in C. elegans. Developmental cell. 2003 Jul;5(1):21–31.
Journal cover image

Published In

Developmental cell

DOI

EISSN

1878-1551

ISSN

1534-5807

Publication Date

July 2003

Volume

5

Issue

1

Start / End Page

21 / 31

Related Subject Headings

  • Vulva
  • Uterus
  • Transgenes
  • Signal Transduction
  • Mutation
  • Luminescent Proteins
  • Green Fluorescent Proteins
  • Gonads
  • Gene Expression Regulation, Developmental
  • Female