Airway epithelium as an effector of inflammation: molecular regulation of secondary mediators.

Journal Article (Review;Journal Article)

Deleterious environmental stimuli cause the airway epithelium to respond with increased secretions of mucus, reaction of oxygen/nitrogen species, changes in ciliary beating, and the influx of inflammatory cells. The epithelium is a target for factors released by infiltrating inflammatory cells, and has recently been shown to serve as an effector of such inflammation. Molecular mechanisms regulating production of secondary inflammatory mediators (cytokines, lipid mediators, and reactive oxygen/nitrogen species) have yet to be fully described. This report reviews the production of secondary mediators by epithelial cells and by airway epithelium. Lipid mediators are enzymatically produced by the airway epithelium in response to primary mediators. Molecular mechanisms regulating the production of cyclo-oxygenase, lipoxygenase and prostaglandin synthase are discussed, along with the potential of lipid mediators to produce inflammation. The molecular regulation of nitric oxide production is also described in the context of its role as a signalling molecule in pathways regulating secretion of mucus, ciliary motion, and intercellular adhesion molecule-1 (ICAM-1) expression. The production of cytokines by the airway epithelium is shown to play a role in causing inflammation associated with respiratory diseases. Particular attention is paid to molecular mechanisms governing the expression of tumour necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and interleukin-8 (IL-8).

Full Text

Duke Authors

Cited Authors

  • Martin, LD; Rochelle, LG; Fischer, BM; Krunkosky, TM; Adler, KB

Published Date

  • September 1997

Published In

Volume / Issue

  • 10 / 9

Start / End Page

  • 2139 - 2146

PubMed ID

  • 9311517

Electronic International Standard Serial Number (EISSN)

  • 1399-3003

International Standard Serial Number (ISSN)

  • 0903-1936

Digital Object Identifier (DOI)

  • 10.1183/09031936.97.10092139


  • eng