A calcium-responsive transcription factor, CaRF, that regulates neuronal activity-dependent expression of BDNF.

Journal Article (Journal Article)

Transcription of the brain-derived neurotrophic factor (BDNF) gene is regulated in a calcium- and neuron-selective manner; however, the mechanisms that underlie this selectivity are not known. We have characterized a new calcium-response element, CaRE1, that is required for activity-dependent transcription of BDNF exon III and have cloned a transcription factor, CaRF, that activates transcription from BDNF promoter III in a CaRE1-dependent manner. The transcriptional activity of CaRF is regulated in a calcium- and neuron-selective manner, suggesting that CaRF may confer selectivity upon the activity-dependent induction of BDNF exon III expression.

Full Text

Duke Authors

Cited Authors

  • Tao, X; West, AE; Chen, WG; Corfas, G; Greenberg, ME

Published Date

  • January 31, 2002

Published In

Volume / Issue

  • 33 / 3

Start / End Page

  • 383 - 395

PubMed ID

  • 11832226

International Standard Serial Number (ISSN)

  • 0896-6273

Digital Object Identifier (DOI)

  • 10.1016/s0896-6273(01)00561-x


  • eng

Conference Location

  • United States