Transcriptional control of cognitive development.

Journal Article (Review)

Cognitive development is determined by both genetics and environment. One point of convergence of these two influences is the neural activity-dependent regulation of programs of gene expression that specify neuronal fate and function. Human genetic studies have linked several transcriptional regulators to neurodevelopmental disorders including mental retardation and autism spectrum disorders. Recent reports on two such factors, CREB-binding protein and methyl-CpG-binding protein 2, have begun to reveal how epigenetics and neuronal activity act to modulate the program of gene expression required for synaptic development and function.

Full Text

Duke Authors

Cited Authors

  • Hong, EJ; West, AE; Greenberg, ME

Published Date

  • February 2005

Published In

Volume / Issue

  • 15 / 1

Start / End Page

  • 21 - 28

PubMed ID

  • 15721740

Electronic International Standard Serial Number (EISSN)

  • 1873-6882

International Standard Serial Number (ISSN)

  • 0959-4388

Digital Object Identifier (DOI)

  • 10.1016/j.conb.2005.01.002

Language

  • eng