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Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons.

Publication ,  Journal Article
Chen, WG; West, AE; Tao, X; Corfas, G; Szentirmay, MN; Sawadogo, M; Vinson, C; Greenberg, ME
Published in: J Neurosci
April 1, 2003

To identify molecular mechanisms that control activity-dependent gene expression in the CNS, we have characterized the factors that mediate activity-dependent transcription of BDNF promoter III. We report the identification of a Ca(2+)-responsive E-box element, CaRE2, within BDNF promoter III that binds upstream stimulatory factors 1 and 2 (USF1/2) and show that USFs are required for the activation of CaRE2-dependent transcription from BDNF promoter III. We find that the transcriptional activity of the USFs is regulated by Ca(2+)-activated signaling pathways in neurons and that the USFs bind to the promoters of a number of neuronal activity-regulated genes in vivo. These results suggest a new function for the USFs in the regulation of activity-dependent transcription in neurons.

Duke Scholars

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

April 1, 2003

Volume

23

Issue

7

Start / End Page

2572 / 2581

Location

United States

Related Subject Headings

  • Upstream Stimulatory Factors
  • Transcriptional Activation
  • Transcription Factors
  • Response Elements
  • Rats, Long-Evans
  • Rats
  • Promoter Regions, Genetic
  • Neurons
  • Neurology & Neurosurgery
  • Mice
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chen, W. G., West, A. E., Tao, X., Corfas, G., Szentirmay, M. N., Sawadogo, M., … Greenberg, M. E. (2003). Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. J Neurosci, 23(7), 2572–2581. https://doi.org/10.1523/JNEUROSCI.23-07-02572.2003
Chen, Wen G., Anne E. West, Xu Tao, Gabriel Corfas, Marilyn N. Szentirmay, Michele Sawadogo, Charles Vinson, and Michael E. Greenberg. “Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons.J Neurosci 23, no. 7 (April 1, 2003): 2572–81. https://doi.org/10.1523/JNEUROSCI.23-07-02572.2003.
Chen WG, West AE, Tao X, Corfas G, Szentirmay MN, Sawadogo M, et al. Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. J Neurosci. 2003 Apr 1;23(7):2572–81.
Chen, Wen G., et al. “Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons.J Neurosci, vol. 23, no. 7, Apr. 2003, pp. 2572–81. Pubmed, doi:10.1523/JNEUROSCI.23-07-02572.2003.
Chen WG, West AE, Tao X, Corfas G, Szentirmay MN, Sawadogo M, Vinson C, Greenberg ME. Upstream stimulatory factors are mediators of Ca2+-responsive transcription in neurons. J Neurosci. 2003 Apr 1;23(7):2572–2581.

Published In

J Neurosci

DOI

EISSN

1529-2401

Publication Date

April 1, 2003

Volume

23

Issue

7

Start / End Page

2572 / 2581

Location

United States

Related Subject Headings

  • Upstream Stimulatory Factors
  • Transcriptional Activation
  • Transcription Factors
  • Response Elements
  • Rats, Long-Evans
  • Rats
  • Promoter Regions, Genetic
  • Neurons
  • Neurology & Neurosurgery
  • Mice