Experimental control of cardiac muscle alternans.


Journal Article

We demonstrate that alternans in small pieces of in vitro paced bullfrog (Rana Catesbeiana) myocardium can be suppressed by making minute adjustments to the pacing period in response to real time measurements of the action potential duration. Control is possible over a large range of physiological conditions over many animals and the self-referencing control protocol can automatically adjust to changes in the pacing interval. Our results suggest the feasibility of developing low-energy methods for maintaining normal cardiac function.

Full Text

Duke Authors

Cited Authors

  • Hall, GM; Gauthier, DJ

Published Date

  • May 2002

Published In

Volume / Issue

  • 88 / 19

Start / End Page

  • 198102 -

PubMed ID

  • 12005667

Pubmed Central ID

  • 12005667

Electronic International Standard Serial Number (EISSN)

  • 1079-7114

International Standard Serial Number (ISSN)

  • 0031-9007

Digital Object Identifier (DOI)

  • 10.1103/physrevlett.88.198102


  • eng