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The Ras-related protein AGS1/RASD1 suppresses cell growth.

Publication ,  Journal Article
Vaidyanathan, G; Cismowski, MJ; Wang, G; Vincent, TS; Brown, KD; Lanier, SM
Published in: Oncogene
July 29, 2004

AGS1/RASD1 is a Ras-related protein identified as a dexamethasone-inducible cDNA and as a signal regulator in various functional and protein-interaction screens. As an initial approach to define the role of AGS1/RASD1 as a Ras-family member, we determined its influence on cell growth/survival. In clonogenic assays with NIH-3T3 murine fibroblast cells, the MCF-7 human breast cancer cell line and the human lung adenocarcinoma cell line A549, AGS1/RASD1 markedly diminished the number of G418-resistant colonies, whereas the Ras subgroup member K-Ras was without effect. A549 cell infection with adenovirus engineered to express AGS1/RASD1 (Ad.AGS1) inhibited log phase growth in vitro and increased the percentage of cells undergoing apoptosis. The anti-growth action was also observed in vivo as the expression of AGS1/RASD1 inhibited the subcutaneous tumor growth of A549 cells in athymic nude mice. These data indicate that AGS1/RASD1, a member of the Ras superfamily of small G-proteins that often promotes cell growth and tumor expansion, plays an active role in preventing aberrant cell growth.

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Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

July 29, 2004

Volume

23

Issue

34

Start / End Page

5858 / 5863

Location

England

Related Subject Headings

  • ras Proteins
  • Tumor Cells, Cultured
  • Pertussis Toxin
  • Oncology & Carcinogenesis
  • Mice, Nude
  • Mice
  • Lung Neoplasms
  • Humans
  • GTP-Binding Proteins
  • Cell Division
 

Citation

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Vaidyanathan, G., Cismowski, M. J., Wang, G., Vincent, T. S., Brown, K. D., & Lanier, S. M. (2004). The Ras-related protein AGS1/RASD1 suppresses cell growth. Oncogene, 23(34), 5858–5863. https://doi.org/10.1038/sj.onc.1207774
Vaidyanathan, Govindan, Mary J. Cismowski, Guoshun Wang, Timothy S. Vincent, Kevin D. Brown, and Stephen M. Lanier. “The Ras-related protein AGS1/RASD1 suppresses cell growth.Oncogene 23, no. 34 (July 29, 2004): 5858–63. https://doi.org/10.1038/sj.onc.1207774.
Vaidyanathan G, Cismowski MJ, Wang G, Vincent TS, Brown KD, Lanier SM. The Ras-related protein AGS1/RASD1 suppresses cell growth. Oncogene. 2004 Jul 29;23(34):5858–63.
Vaidyanathan, Govindan, et al. “The Ras-related protein AGS1/RASD1 suppresses cell growth.Oncogene, vol. 23, no. 34, July 2004, pp. 5858–63. Pubmed, doi:10.1038/sj.onc.1207774.
Vaidyanathan G, Cismowski MJ, Wang G, Vincent TS, Brown KD, Lanier SM. The Ras-related protein AGS1/RASD1 suppresses cell growth. Oncogene. 2004 Jul 29;23(34):5858–5863.

Published In

Oncogene

DOI

ISSN

0950-9232

Publication Date

July 29, 2004

Volume

23

Issue

34

Start / End Page

5858 / 5863

Location

England

Related Subject Headings

  • ras Proteins
  • Tumor Cells, Cultured
  • Pertussis Toxin
  • Oncology & Carcinogenesis
  • Mice, Nude
  • Mice
  • Lung Neoplasms
  • Humans
  • GTP-Binding Proteins
  • Cell Division