Transduction of receptor signals by beta-arrestins.

Journal Article (Journal Article;Review)

The transmission of extracellular signals to the interior of the cell is a function of plasma membrane receptors, of which the seven transmembrane receptor family is by far the largest and most versatile. Classically, these receptors stimulate heterotrimeric G proteins, which control rates of generation of diffusible second messengers and entry of ions at the plasma membrane. Recent evidence, however, indicates another previously unappreciated strategy used by the receptors to regulate intracellular signaling pathways. They direct the recruitment, activation, and scaffolding of cytoplasmic signaling complexes via two multifunctional adaptor and transducer molecules, beta-arrestins 1 and 2. This mechanism regulates aspects of cell motility, chemotaxis, apoptosis, and likely other cellular functions through a rapidly expanding list of signaling pathways.

Full Text

Duke Authors

Cited Authors

  • Lefkowitz, RJ; Shenoy, SK

Published Date

  • April 22, 2005

Published In

Volume / Issue

  • 308 / 5721

Start / End Page

  • 512 - 517

PubMed ID

  • 15845844

Electronic International Standard Serial Number (EISSN)

  • 1095-9203

Digital Object Identifier (DOI)

  • 10.1126/science.1109237


  • eng

Conference Location

  • United States