D-amphetamine in obsessive-compulsive disorder.

Journal Article (Clinical Trial;Journal Article)

In a double-blind crossover study, single doses of d-amphetamine and placebo were administered to 12 patients with severe chronic obsessive-compulsive disorder (OCD). Improvement of obsessional symptoms was significant on clinical ratings and was correlated with improved performance on an attention task. Changes were also significant for self-rated measures of activation and altered reality. The behavior response to amphetamine was not statistically correlated with subsequent improvement during a 6-week clomipramine trial, although the direction of change was the same during both treatments for every patient studied.

Full Text

Duke Authors

Cited Authors

  • Insel, TR; Hamilton, JA; Guttmacher, LB; Murphy, DL

Published Date

  • January 1, 1983

Published In

Volume / Issue

  • 80 / 3

Start / End Page

  • 231 - 235

PubMed ID

  • 6412267

Electronic International Standard Serial Number (EISSN)

  • 1432-2072

International Standard Serial Number (ISSN)

  • 0033-3158

Digital Object Identifier (DOI)

  • 10.1007/bf00436159


  • eng