Behavioral indications for serotonin receptor hypersensitivity in panic disorder.

Journal Article (Journal Article)

Immediate placebo-corrected behavioral responses to m-chlorophenylpiperazine (MCPP), a selective serotonin agonist, are reported in 11 normal controls, 10 patients with panic disorder, and 10 patients with major depression. Whereas the normal and depressed groups showed no noteworthy behavioral response, panic disorder patients became more anxious, depressed, and hostile, and 60% had panic attacks. These data suggest a hypersensitive postsynaptic serotonin receptor system in some panic disorder patients.

Full Text

Published version (via Digital Object Identifier)

Duke Authors

Strauman, Timothy J.

Cited Authors

Kahn, RS; Wetzler, S; van Praag, HM; Asnis, GM; Strauman, T

Published Date

July 1988

Published In

Psychiatry Research

Volume / Issue

25 / 1

Start / End Page

101 - 104

PubMed ID

3217461

Electronic International Standard Serial Number (EISSN)

1872-7123

International Standard Serial Number (ISSN)

0165-1781

Digital Object Identifier (DOI)

10.1016/0165-1781(88)90163-1

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