Behavioral indications for serotonin receptor hypersensitivity in panic disorder.

Journal Article (Journal Article)

Immediate placebo-corrected behavioral responses to m-chlorophenylpiperazine (MCPP), a selective serotonin agonist, are reported in 11 normal controls, 10 patients with panic disorder, and 10 patients with major depression. Whereas the normal and depressed groups showed no noteworthy behavioral response, panic disorder patients became more anxious, depressed, and hostile, and 60% had panic attacks. These data suggest a hypersensitive postsynaptic serotonin receptor system in some panic disorder patients.

Full Text

Duke Authors

Cited Authors

  • Kahn, RS; Wetzler, S; van Praag, HM; Asnis, GM; Strauman, T

Published Date

  • July 1988

Published In

Volume / Issue

  • 25 / 1

Start / End Page

  • 101 - 104

PubMed ID

  • 3217461

Electronic International Standard Serial Number (EISSN)

  • 1872-7123

International Standard Serial Number (ISSN)

  • 0165-1781

Digital Object Identifier (DOI)

  • 10.1016/0165-1781(88)90163-1


  • eng