Diffusion/microcirculation MRI in the rat brain.

Journal Article (Journal Article)

The CO2 fraction of an anesthetized rat's breathing mixture was changed (from 0 to 10%) to attempt to change the brain microcirculation and observe these changes in diffusion measurements of the neural tissue. Brain apparent diffusion coefficients were measured to be (0.71 +/- 0.01) X 10(-3) mm2/s before sacrifice and (0.39 +/- 0.01) X 10(-3) mm2/s after sacrifice. Multiple diffusion components were observed, consistent with flowing material, but the extra components did not increase with increased CO2. It is proposed that the additional components may be due to extracellular, extravascular water such as CSF.

Full Text

Duke Authors

Cited Authors

  • MacFall, JR; Maki, JH; Johnson, GA; Hedlund, L; Benveniste, H; Copher, G

Published Date

  • June 1991

Published In

Volume / Issue

  • 19 / 2

Start / End Page

  • 305 - 310

PubMed ID

  • 1908936

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.1910190219


  • eng

Conference Location

  • United States