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MR imaging of microcirculation in rat brain: correlation with carbon dioxide-induced changes in blood flow.

Publication ,  Journal Article
Maki, JH; Benveniste, H; MacFall, JR; Piantadosi, CA; Johnson, GA
Published in: J Magn Reson Imaging
1991

Considerable interest has been shown in developing a magnetic resonance (MR) imaging technique with quantitative capability in the evaluation of tissue microcirculation ("perfusion"). In the present study, the flow-dephased/flow-compensated (FD/FC) technique is evaluated for measuring rat cerebral blood flow (CBF) under nearly optimal laboratory conditions. Imaging was performed on a 2.0-T system equipped with shielded gradient coils. Rat CBF was varied by manipulating arterial carbon dioxide pressure (PaCO2). In parallel experiments, optimized MR imaging studies (seven rats) were compared with laser Doppler flowmetry (LDF) studies (nine rats). LDF values showed a high degree of correlation between CBF and PaCO2, agreeing with results in the literature. MR imaging values, while correlating with PaCO2, showed considerable scatter. The most likely explanation is unavoidable rat motion during the requisite long imaging times. Because of this motion sensitivity, the FD/FC technique cannot provide a quantitative measure of CBF. It can, however, provide a qualitative picture.

Duke Scholars

Published In

J Magn Reson Imaging

DOI

ISSN

1053-1807

Publication Date

1991

Volume

1

Issue

6

Start / End Page

673 / 681

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Nuclear Medicine & Medical Imaging
  • Motion
  • Models, Structural
  • Microcirculation
  • Magnetic Resonance Imaging
  • Linear Models
  • Lasers
  • Image Enhancement
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Maki, J. H., Benveniste, H., MacFall, J. R., Piantadosi, C. A., & Johnson, G. A. (1991). MR imaging of microcirculation in rat brain: correlation with carbon dioxide-induced changes in blood flow. J Magn Reson Imaging, 1(6), 673–681. https://doi.org/10.1002/jmri.1880010609
Maki, J. H., H. Benveniste, J. R. MacFall, C. A. Piantadosi, and G. A. Johnson. “MR imaging of microcirculation in rat brain: correlation with carbon dioxide-induced changes in blood flow.J Magn Reson Imaging 1, no. 6 (1991): 673–81. https://doi.org/10.1002/jmri.1880010609.
Maki JH, Benveniste H, MacFall JR, Piantadosi CA, Johnson GA. MR imaging of microcirculation in rat brain: correlation with carbon dioxide-induced changes in blood flow. J Magn Reson Imaging. 1991;1(6):673–81.
Maki, J. H., et al. “MR imaging of microcirculation in rat brain: correlation with carbon dioxide-induced changes in blood flow.J Magn Reson Imaging, vol. 1, no. 6, 1991, pp. 673–81. Pubmed, doi:10.1002/jmri.1880010609.
Maki JH, Benveniste H, MacFall JR, Piantadosi CA, Johnson GA. MR imaging of microcirculation in rat brain: correlation with carbon dioxide-induced changes in blood flow. J Magn Reson Imaging. 1991;1(6):673–681.
Journal cover image

Published In

J Magn Reson Imaging

DOI

ISSN

1053-1807

Publication Date

1991

Volume

1

Issue

6

Start / End Page

673 / 681

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Nuclear Medicine & Medical Imaging
  • Motion
  • Models, Structural
  • Microcirculation
  • Magnetic Resonance Imaging
  • Linear Models
  • Lasers
  • Image Enhancement