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In vitro MR microscopy of the hippocampus in Alzheimer's disease.

Publication ,  Journal Article
Huesgen, CT; Burger, PC; Crain, BJ; Johnson, GA
Published in: Neurology
January 1993

We used MR microscopy at 7 tesla to identify the anatomy of the degenerating hippocampus in Alzheimer's disease (AD), which we then correlated with the histopathologic findings in the same specimens. The specimens studied were resected postmortem from 13 patients with confirmed AD and from nine age-matched controls. We imaged the specimens in the coronal plane using either three-dimensional Fourier encoding or single-slice Carr, Purcell, Meiboom, Gill (CPMG) spin echo sequences. On all specimens imaged with the CPMG pulse sequence, we calculated the T2 relaxation times for subfields within the hippocampus. Histologic sections were taken from each specimen and compared with the corresponding MR image. Using histologic boundaries, we quantified the number of neuritic plaques and neurofibrillary tangles in each hippocampal subfield. We measured the area, morphometric characteristics, and width of identifiable signal variant regions on each image and compared these measurements with the histopathologic findings. The mean cross-sectional area of the hippocampus in AD was decreased by 31% compared with the control group. This atrophy was highly correlated with tangle counts within the hippocampus, but not with plaque counts. The width of the gray matter in hippocampal area CA1, as identified by MR, correlated with the total area of the hippocampus. An age-related decrease in the size of a low-signal region that corresponds histologically to input projections comprising part of the perforant pathway was identified. Measurements of the T2 relaxation times of hippocampal subfields showed little regional variability and were not accurate indicators of disease presence or severity (p > 0.05).

Duke Scholars

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

January 1993

Volume

43

Issue

1

Start / End Page

145 / 152

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Neurofibrillary Tangles
  • Middle Aged
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Fourier Analysis
  • Alzheimer Disease
  • Aged, 80 and over
  • Aged
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Huesgen, C. T., Burger, P. C., Crain, B. J., & Johnson, G. A. (1993). In vitro MR microscopy of the hippocampus in Alzheimer's disease. Neurology, 43(1), 145–152. https://doi.org/10.1212/wnl.43.1_part_1.145
Huesgen, C. T., P. C. Burger, B. J. Crain, and G. A. Johnson. “In vitro MR microscopy of the hippocampus in Alzheimer's disease.Neurology 43, no. 1 (January 1993): 145–52. https://doi.org/10.1212/wnl.43.1_part_1.145.
Huesgen CT, Burger PC, Crain BJ, Johnson GA. In vitro MR microscopy of the hippocampus in Alzheimer's disease. Neurology. 1993 Jan;43(1):145–52.
Huesgen, C. T., et al. “In vitro MR microscopy of the hippocampus in Alzheimer's disease.Neurology, vol. 43, no. 1, Jan. 1993, pp. 145–52. Pubmed, doi:10.1212/wnl.43.1_part_1.145.
Huesgen CT, Burger PC, Crain BJ, Johnson GA. In vitro MR microscopy of the hippocampus in Alzheimer's disease. Neurology. 1993 Jan;43(1):145–152.

Published In

Neurology

DOI

ISSN

0028-3878

Publication Date

January 1993

Volume

43

Issue

1

Start / End Page

145 / 152

Location

United States

Related Subject Headings

  • Neurology & Neurosurgery
  • Neurofibrillary Tangles
  • Middle Aged
  • Magnetic Resonance Imaging
  • Humans
  • Hippocampus
  • Fourier Analysis
  • Alzheimer Disease
  • Aged, 80 and over
  • Aged