In vivo measurement of proton diffusion in the presence of coherent motion.

Journal Article (Journal Article)

Measurement of the self-diffusion coefficient D of water in tissue has been performed traditionally using the technique proposed by Stejskal and Tanner. A variant of that technique is shown here, employing flow-compensated gradients that significantly reduce the sensitivity to small coherent motions that are common in body imaging. An interleaved sequence with four values of diffusion-sensitizing gradient (b) minimizes registration errors. Eddy currents and other systematic errors are reduced, permitting the measurement of standards in an imaging context within 5% of nonimaging values in the literature. The flow-compensated sequence permits the measure of D for tissues in the abdominal cavity of the rat. We present in vivo measurements of D for the following rat tissues; liver, kidney (cortex), kidney (medulla) muscle, brain, fat.

Full Text

Duke Authors

Cited Authors

  • Johnson, GA; Maki, JH

Published Date

  • June 1991

Published In

Volume / Issue

  • 26 / 6

Start / End Page

  • 540 - 545

PubMed ID

  • 1650333

International Standard Serial Number (ISSN)

  • 0020-9996

Digital Object Identifier (DOI)

  • 10.1097/00004424-199106000-00006


  • eng

Conference Location

  • United States