In vivo measurement of proton diffusion in the presence of coherent motion.
Journal Article (Journal Article)
Measurement of the self-diffusion coefficient D of water in tissue has been performed traditionally using the technique proposed by Stejskal and Tanner. A variant of that technique is shown here, employing flow-compensated gradients that significantly reduce the sensitivity to small coherent motions that are common in body imaging. An interleaved sequence with four values of diffusion-sensitizing gradient (b) minimizes registration errors. Eddy currents and other systematic errors are reduced, permitting the measurement of standards in an imaging context within 5% of nonimaging values in the literature. The flow-compensated sequence permits the measure of D for tissues in the abdominal cavity of the rat. We present in vivo measurements of D for the following rat tissues; liver, kidney (cortex), kidney (medulla) muscle, brain, fat.
Full Text
Duke Authors
Cited Authors
- Johnson, GA; Maki, JH
Published Date
- June 1991
Published In
Volume / Issue
- 26 / 6
Start / End Page
- 540 - 545
PubMed ID
- 1650333
International Standard Serial Number (ISSN)
- 0020-9996
Digital Object Identifier (DOI)
- 10.1097/00004424-199106000-00006
Language
- eng
Conference Location
- United States