Magnetic resonance microscopy of embryos.

Journal Article (Journal Article)

We demonstrate that magnetic resonance (MR) microscopy provides a mechanism to investigate normal and abnormal developmental anatomy in a non-destructive and distortion-free manner. Techniques for the fixation, embedding, perfusion and image acquisition of embryos between 3 and 30 mm crown rump length are described. We describe the perfusion of a contrast agent to enhance images of the developing embryonic vasculature. Data are acquired as three-dimensional isotropic arrays which permit images to be reformatted retrospectively in any plane. The data are available for archiving, distributing and for post-acquisition manipulations. MR microscopy is a fast technique for producing three-dimensional reconstructions and is free from registration and sectioning artifacts.

Full Text

Duke Authors

Cited Authors

  • Smith, BR; Linney, E; Huff, DS; Johnson, GA

Published Date

  • 1996

Published In

Volume / Issue

  • 20 / 6

Start / End Page

  • 483 - 490

PubMed ID

  • 9007215

International Standard Serial Number (ISSN)

  • 0895-6111

Digital Object Identifier (DOI)

  • 10.1016/s0895-6111(96)00046-8


  • eng

Conference Location

  • United States