Hyperpolarized 3He NMR lineshape measurements in the live guinea pig lung.

Journal Article (Journal Article)

Spatially localized lineshapes of hyperpolarized (HP) 3He in guinea pig lungs have been measured in vivo. Three different axial slice locations, each containing different compositions of airway sizes and orientations, were studied. Gas peaks from major bronchi (2 ppm) and alveoli (-2 ppm) were distinguished. The gas phase spectra show structural features that are a result of frequency shifts caused by bulk magnetic susceptibility. For a given slice, the spectral lineshapes reflect the airway composition within the slice location, according to theory. The peak assignments given here also agree with previous studies done by Wagshul et al. with HP 129Xe. At each of the slice locations, data were acquired during two phases of the breathing cycle, resulting in a relative frequency shift of approximately 0.3 ppm in the superior slices. Spectra obtained over a number of breaths show the dynamics of the gas buildup in the lung and provide further evidence supporting the peak assignments.

Full Text

Duke Authors

Cited Authors

  • Chen, XJ; Chawla, MS; Cofer, GP; Hedlund, LW; Möller, HE; Johnson, GA

Published Date

  • July 1998

Published In

Volume / Issue

  • 40 / 1

Start / End Page

  • 61 - 65

PubMed ID

  • 9660554

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/mrm.1910400109


  • eng

Conference Location

  • United States