MR microscopy of chick embryo vasculature.

Journal Article (Journal Article)

Six-day-old chick embryos were examined with magnetic resonance microscopy after vascular perfusion fixation and perfusion with gadolinium-doped gelatin to high-light the developing vascular anatomy. Gadolinium gelatin, with its short T1, provided a source of signal contrast within the vessels. The entire embryo was embedded in gelatin to minimize susceptibility artifacts that are prevalent at the high field strength (7.0 T) used. A series of single-section spin-echo images were acquired with various TRs to determine the optimal imaging sequence for a three-dimensional (3D) acquisition. The combination of gadolinium gelatin in the vascular spaces, gelatin embedding of the specimen, and optimal acquisition parameters yielded a 3D stack of high-resolution images that was readily reconstructed and rendered to effectively demonstrate the developing thoracic vessels in the embryo.

Full Text

Duke Authors

Cited Authors

  • Smith, BR; Effmann, EL; Johnson, GA

Published Date

  • 1992

Published In

Volume / Issue

  • 2 / 2

Start / End Page

  • 237 - 240

PubMed ID

  • 1562778

International Standard Serial Number (ISSN)

  • 1053-1807

Digital Object Identifier (DOI)

  • 10.1002/jmri.1880020220


  • eng

Conference Location

  • United States