T1rho imaging using magnetization-prepared projection encoding (MaPPE).

Journal Article

T1rho contrast weighting using a magnetization-prepared projection encoding (MaPPE) pulse sequence was investigated. Fast radial imaging was implemented by applying magnetization preparation pulses, each followed by multiple RF alpha pulses encoding radial trajectories of k-space. Acquiring multiple views per preparatory pulse imposes view-to-view variation; the resultant distortion of the point-spread function is examined. The issue of maximizing signal while preserving the intended contrast weighting is addressed. Under modification of repetition time and flip angle (alpha), three distinct behavior regimes of the sequence are identified. The utility of the pulse sequence as a quantitative relaxation measurement tool is also examined by comparing imaging and spectroscopy experiments. A mouse was imaged in vitro to demonstrate the viability of application to MR histology. These images exhibit the utility of spinlocking and projection encoding as an aftemative contrast source to both T2-weighted MaPPE images and conventional T2-weighted spin-echo images.

Full Text

Duke Authors

Cited Authors

  • Nugent, AC; Johnson, GA

Published Date

  • March 2000

Published In

Volume / Issue

  • 43 / 3

Start / End Page

  • 421 - 428

PubMed ID

  • 10725885

Pubmed Central ID

  • 10725885

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/(sici)1522-2594(200003)43:3<421::aid-mrm14>3.0.co;2-x


  • eng

Conference Location

  • United States