Functional MR microscopy of the lung using hyperpolarized 3He.

Journal Article (Journal Article)

A new strategy designed to provide functional magnetic resonance images of the lung in small animals at microscopic resolution using hyperpolarized 3He is described. The pulse sequence is based on a combination of radial acquisition (RA) and CINE techniques, referred to as RA-CINE, and is designed for use with hyperpolarized 3He to explore lung ventilation with high temporal and spatial resolution in small animal models. Ventilation of the live guinea pig is demonstrated with effective temporal resolution of 50 msec and in-plane spatial resolution of <100 microm using hyperpolarized 3He. The RA-CINE sequence allows one to follow gas inflow and outflow in the airways as well as in the distal part of the lungs. Regional analysis of signal intensity variations can be performed and can help assess functional lung parameters such as residual gas volume and lung compliance to gas inflow.

Full Text

Duke Authors

Cited Authors

  • Viallon, M; Cofer, GP; Suddarth, SA; Möller, HE; Chen, XJ; Chawla, MS; Hedlund, LW; Crémillieux, Y; Johnson, GA

Published Date

  • April 1999

Published In

Volume / Issue

  • 41 / 4

Start / End Page

  • 787 - 792

PubMed ID

  • 10332855

International Standard Serial Number (ISSN)

  • 0740-3194

Digital Object Identifier (DOI)

  • 10.1002/(sici)1522-2594(199904)41:4<787::aid-mrm18>;2-4


  • eng

Conference Location

  • United States