Progression of a focal ischemic lesion in rat brain during treatment with a novel glycine/NMDA antagonist: an in vivo three-dimensional diffusion-weighted MR microscopy study.
Journal Article (Journal Article)
Stroke was induced in two groups of anesthetized rats by occlusion of the middle cerebral artery (MCA) and ipsilateral common carotid artery. Group 1 (control) received vehicle and group 2 received the glycine N-methyl-D-aspartate (NMDA) antagonist ZD9379. Stroke volume was assessed by three-dimensional diffusion-weighted MR microscopy at 2.5 and 6 hours of MCA occlusion. At 2.5 hours, stroke volumes were identical in the two groups. At 6 hours, stroke volumes had increased by 15% in the control group; in contrast, the treated group showed a 40% reduced stroke volume. Conclusions from this in vivo study were as follows: (a) our technique allows more efficient and accurate measurement of stroke volume with an improvement in resolution over a previous method; (b) the ability to measure stroke volume at multiple time points shows volume change and assessment of time dependency of drug treatment; (c) at 6 hours, the glycine antagonist ZD9379 reduced stroke volume by 40%.
Full Text
Duke Authors
Cited Authors
- Qiu, H; Hedlund, LW; Gewalt, SL; Benveniste, H; Bare, TM; Johnson, GA
Published Date
- 1997
Published In
Volume / Issue
- 7 / 4
Start / End Page
- 739 - 744
PubMed ID
- 9243396
International Standard Serial Number (ISSN)
- 1053-1807
Digital Object Identifier (DOI)
- 10.1002/jmri.1880070421
Language
- eng
Conference Location
- United States