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Responsiveness to alpha- and beta-adrenergic receptor agonists. Effects of race in borderline hypertensive compared to normotensive men.

Publication ,  Journal Article
Sherwood, A; Hinderliter, AL
Published in: Am J Hypertens
July 1993

The responsiveness of alpha- and beta-adrenergic receptors was assessed in 13 black and 13 white borderline hypertensive and normotensive men, matched for age and body mass. White borderline hypertensives showed significantly decreased responsiveness of cardiac beta-adrenergic receptors and vascular beta 2-adrenergic receptors to intravenous isoproterenol. In contrast, black borderline hypertensives showed no evidence of decreased beta-adrenergic receptor responsiveness. Vascular alpha 1-adrenergic receptor responsiveness, assessed by pressor response to phenylephrine, was unrelated to blood pressure, but was significantly greater in black than in white men. These preliminary observations suggest that there may be racial differences in adrenergic receptor mechanisms involved in the pathogenesis of hypertension.

Duke Scholars

Published In

Am J Hypertens

DOI

ISSN

0895-7061

Publication Date

July 1993

Volume

6

Issue

7 Pt 1

Start / End Page

630 / 635

Location

United States

Related Subject Headings

  • White People
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Phenylephrine
  • Male
  • Isoproterenol
  • Hypertension
  • Humans
  • Case-Control Studies
  • Cardiovascular System & Hematology
 

Citation

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Sherwood, A., & Hinderliter, A. L. (1993). Responsiveness to alpha- and beta-adrenergic receptor agonists. Effects of race in borderline hypertensive compared to normotensive men. Am J Hypertens, 6(7 Pt 1), 630–635. https://doi.org/10.1093/ajh/6.7.630
Sherwood, A., and A. L. Hinderliter. “Responsiveness to alpha- and beta-adrenergic receptor agonists. Effects of race in borderline hypertensive compared to normotensive men.Am J Hypertens 6, no. 7 Pt 1 (July 1993): 630–35. https://doi.org/10.1093/ajh/6.7.630.
Sherwood, A., and A. L. Hinderliter. “Responsiveness to alpha- and beta-adrenergic receptor agonists. Effects of race in borderline hypertensive compared to normotensive men.Am J Hypertens, vol. 6, no. 7 Pt 1, July 1993, pp. 630–35. Pubmed, doi:10.1093/ajh/6.7.630.
Journal cover image

Published In

Am J Hypertens

DOI

ISSN

0895-7061

Publication Date

July 1993

Volume

6

Issue

7 Pt 1

Start / End Page

630 / 635

Location

United States

Related Subject Headings

  • White People
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Phenylephrine
  • Male
  • Isoproterenol
  • Hypertension
  • Humans
  • Case-Control Studies
  • Cardiovascular System & Hematology