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Hostility and adrenergic receptor responsiveness: evidence of reduced beta-receptor responsiveness in high hostile men.

Publication ,  Journal Article
Suarez, EC; Sherwood, A; Hinderliter, AL
Published in: J Psychosom Res
February 1998

We examined the relation of Cook and Medley Hostility (Ho) scores to alpha- and beta-adrenergic receptor responsiveness to pharmacological agonists in 22 normotensive and 14 hypertensives (aged 18-34) white males, matched for age and body mass. alpha-Adrenergic receptor responsiveness was measured by the phenylephrine dose required to increase mean blood pressure by 25 mmHg (PD25). beta-Adrenergic responsiveness was measured by the isoproterenol dose needed to increase heart rate by 25 bpm (CD25), and to lower systemic vascular resistance by 40% (VD40). Relative to men with low Ho scores (< or = 21), men with high Ho scores (> or = 21) showed significantly reduced vascular beta 2-adrenergic receptor responsiveness (VD40). Moreover, the decreased vascular responsiveness was more pronounced in borderline hypertensive men with high Ho scores. Ho scores were also marginally significant in predicting cardiac beta 1- and beta 2-adrenergic receptor responsiveness, such that men with high Ho scores showed decreased responsiveness as indexed by a larger CD25. Vascular alpha 1-adrenergic responsiveness was not associated with hostility. These observations suggest that hostility, alone or in conjunction with BP status, is associated with reduced cardiovascular beta-adrenergic receptor responsiveness.

Duke Scholars

Published In

J Psychosom Res

DOI

ISSN

0022-3999

Publication Date

February 1998

Volume

44

Issue

2

Start / End Page

261 / 267

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Psychiatry
  • Predictive Value of Tests
  • Phenylephrine
  • Male
  • Isoproterenol
  • Hypertension
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
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Suarez, E. C., Sherwood, A., & Hinderliter, A. L. (1998). Hostility and adrenergic receptor responsiveness: evidence of reduced beta-receptor responsiveness in high hostile men. J Psychosom Res, 44(2), 261–267. https://doi.org/10.1016/s0022-3999(97)00201-8
Suarez, E. C., A. Sherwood, and A. L. Hinderliter. “Hostility and adrenergic receptor responsiveness: evidence of reduced beta-receptor responsiveness in high hostile men.J Psychosom Res 44, no. 2 (February 1998): 261–67. https://doi.org/10.1016/s0022-3999(97)00201-8.
Suarez EC, Sherwood A, Hinderliter AL. Hostility and adrenergic receptor responsiveness: evidence of reduced beta-receptor responsiveness in high hostile men. J Psychosom Res. 1998 Feb;44(2):261–7.
Suarez, E. C., et al. “Hostility and adrenergic receptor responsiveness: evidence of reduced beta-receptor responsiveness in high hostile men.J Psychosom Res, vol. 44, no. 2, Feb. 1998, pp. 261–67. Pubmed, doi:10.1016/s0022-3999(97)00201-8.
Suarez EC, Sherwood A, Hinderliter AL. Hostility and adrenergic receptor responsiveness: evidence of reduced beta-receptor responsiveness in high hostile men. J Psychosom Res. 1998 Feb;44(2):261–267.
Journal cover image

Published In

J Psychosom Res

DOI

ISSN

0022-3999

Publication Date

February 1998

Volume

44

Issue

2

Start / End Page

261 / 267

Location

England

Related Subject Headings

  • Severity of Illness Index
  • Receptors, Adrenergic, beta
  • Receptors, Adrenergic, alpha
  • Psychiatry
  • Predictive Value of Tests
  • Phenylephrine
  • Male
  • Isoproterenol
  • Hypertension
  • Humans