Enhancing Recovery in Coronary Heart Disease (ENRICHD) study intervention: rationale and design.

Journal Article (Clinical Trial;Journal Article;Multicenter Study)

OBJECTIVE: Depression and low social support are risk factors for medical morbidity and mortality after acute MI. The ENRICHD study is a multicenter, randomized, controlled clinical trial of a cognitive-behavioral treatment for depression and low social support in post-MI patients. A total of 2481 patients were recruited (26% with low social support, 39% with depression, and 34% with low social support and depression). Our objective is to describe the rationale, design, and delivery of the ENRICHD intervention. METHODS: Key features of the intervention include the integration of cognitive-behavioral and social learning approaches to the treatment of depression and a diverse set of problems that can contribute to low social support; rapid initiation of treatment after MI; a combination of individual and group modalities; adjunctive pharmacotherapy for severe or intractable depression; training, certification, and supervision of therapists; and quality assurance procedures. RESULTS: The trial's psychosocial and medical outcomes will be presented in future reports. CONCLUSIONS: The ENRICHD protocol targets two complex psychosocial risk factors with a multifaceted intervention, which is delivered in an individualized manner to accommodate a demographically, medically, and psychiatrically diverse patient population. Additional research will be needed to identify optimal matches between patient characteristics and specific components of the intervention.

Full Text

Duke Authors

Cited Authors

  • ENRICHD Investigators,

Published Date

  • 2001

Published In

Volume / Issue

  • 63 / 5

Start / End Page

  • 747 - 755

PubMed ID

  • 11573023

International Standard Serial Number (ISSN)

  • 0033-3174


  • eng

Conference Location

  • United States