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Cryosurgery after chemoembolization for hepatocellular carcinoma in patients with cirrhosis.

Publication ,  Journal Article
Clavien, P-A; Kang, KJ; Selzner, N; Morse, MA; Suhocki, PV
Published in: J Gastrointest Surg
2002

Most cirrhotic patients with hepatocellular carcinoma (HCC) are not candidates for resection. Transarterial chemoembolization (TACE) may ablate a significant portion of the tumor but has a high rate of recurrence. Cryosurgery may permit successful ablation of hepatic tumors but can be complicated by postoperative hemorrhage and is also associated with a significant risk of recurrence. The combination of the two techniques might be beneficial. We evaluated in a prospective study the safety and efficacy of this combination in cirrhotic patients with unresectable HCC. Fifteen patients were included in this study. All but one patient underwent one or several sessions of TACE before cryosurgery. Cryoablation was successfully performed in each patient. The patient who did not undergo preoperative TACE required reoperation for hemorrhage. Another patient with Child-Pugh class B cirrhosis died postoperatively of hepatic and multiorgan failure. At a mean follow-up of 2.5 years, three patients had recurrence of disease, and 13 of 15 patients were alive with the longest survival time being 5 years. The actuarial survival rate at 5 years was 79%. Cryosurgery after TACE is feasible in cirrhotic livers with HCC and can increase the cure rate in large tumors. TACE may reduce the risk of hemorrhage after cryosurgery but can increase the risk of hepatic failure in patients with poor hepatic function.

Duke Scholars

Published In

J Gastrointest Surg

DOI

ISSN

1091-255X

Publication Date

2002

Volume

6

Issue

1

Start / End Page

95 / 101

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Time Factors
  • Survival Rate
  • Surgery
  • Prospective Studies
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Magnetic Resonance Angiography
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Clavien, P.-A., Kang, K. J., Selzner, N., Morse, M. A., & Suhocki, P. V. (2002). Cryosurgery after chemoembolization for hepatocellular carcinoma in patients with cirrhosis. J Gastrointest Surg, 6(1), 95–101. https://doi.org/10.1016/s1091-255x(01)00037-3
Clavien, Pierre-Alain, Koo Jeong Kang, Nazia Selzner, Michael A. Morse, and Paul V. Suhocki. “Cryosurgery after chemoembolization for hepatocellular carcinoma in patients with cirrhosis.J Gastrointest Surg 6, no. 1 (2002): 95–101. https://doi.org/10.1016/s1091-255x(01)00037-3.
Clavien P-A, Kang KJ, Selzner N, Morse MA, Suhocki PV. Cryosurgery after chemoembolization for hepatocellular carcinoma in patients with cirrhosis. J Gastrointest Surg. 2002;6(1):95–101.
Clavien, Pierre-Alain, et al. “Cryosurgery after chemoembolization for hepatocellular carcinoma in patients with cirrhosis.J Gastrointest Surg, vol. 6, no. 1, 2002, pp. 95–101. Pubmed, doi:10.1016/s1091-255x(01)00037-3.
Clavien P-A, Kang KJ, Selzner N, Morse MA, Suhocki PV. Cryosurgery after chemoembolization for hepatocellular carcinoma in patients with cirrhosis. J Gastrointest Surg. 2002;6(1):95–101.
Journal cover image

Published In

J Gastrointest Surg

DOI

ISSN

1091-255X

Publication Date

2002

Volume

6

Issue

1

Start / End Page

95 / 101

Location

Netherlands

Related Subject Headings

  • Treatment Outcome
  • Tomography, X-Ray Computed
  • Time Factors
  • Survival Rate
  • Surgery
  • Prospective Studies
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Magnetic Resonance Angiography