The importance of repairing stalled replication forks.

Published

Journal Article

The bacterial SOS response to unusual levels of DNA damage has been recognized and studied for several decades. Pathways for re-establishing inactivated replication forks under normal growth conditions have received far less attention. In bacteria growing aerobically in the absence of SOS-inducing conditions, many replication forks encounter DNA damage, leading to inactivation. The pathways for fork reactivation involve the homologous recombination systems, are nonmutagenic, and integrate almost every aspect of DNA metabolism. On a frequency-of-use basis, these pathways represent the main function of bacterial DNA recombination systems, as well as the main function of a number of other enzymatic systems that are associated with replication and site-specific recombination.

Full Text

Duke Authors

Cited Authors

  • Cox, MM; Goodman, MF; Kreuzer, KN; Sherratt, DJ; Sandler, SJ; Marians, KJ

Published Date

  • 2000-03-02

Published In

Volume / Issue

  • 404 / 6773

Start / End Page

  • 37 - 41

PubMed ID

  • 10716434

Pubmed Central ID

  • 10716434

International Standard Serial Number (ISSN)

  • 0028-0836

Digital Object Identifier (DOI)

  • 10.1038/35003501

Language

  • eng

Conference Location

  • England