Recombination-dependent DNA replication in phage T4.


Journal Article (Review)

Studies in the 1960s implied that bacteriophage T4 tightly couples DNA replication to genetic recombination. This contradicted the prevailing wisdom of the time, which staunchly supported recombination as a simple cut-and-paste process. More-recent investigations have shown how recombination triggers DNA synthesis and why the coupling of these two processes is important. Results from T4 were instrumental in our understanding of many important replication and recombination proteins, including the newly recognized replication/recombination mediator proteins. Recombination-dependent DNA replication is crucial to the T4 life cycle as it is the major mode of DNA replication and is also central to the repair of DNA breaks and other damage.

Full Text

Duke Authors

Cited Authors

  • Kreuzer, KN

Published Date

  • April 2000

Published In

Volume / Issue

  • 25 / 4

Start / End Page

  • 165 - 173

PubMed ID

  • 10754548

Pubmed Central ID

  • 10754548

International Standard Serial Number (ISSN)

  • 0968-0004

Digital Object Identifier (DOI)

  • 10.1016/s0968-0004(00)01559-0


  • eng

Conference Location

  • England