Interplay between DNA replication and recombination in prokaryotes.


Journal Article

The processes of DNA replication and recombination are intertwined at many different levels. In diverse systems, extensive DNA replication can be triggered by genetic recombination, with assembly of a replication complex onto a D-loop recombination intermediate. This and related pathways of replisome assembly allow the completion of DNA replication when forks initiated at a conventional replication origin fail before completing replication of the genome. In addition, the repair of double-strand breaks or gaps by homologous recombination requires at least limited DNA replication to replace the missing information. An intricate interplay between replication and recombination is also evident during the termination of bacterial DNA replication and during the induction of the bacterial SOS response to DNA damage.

Full Text

Duke Authors

Cited Authors

  • Kreuzer, KN

Published Date

  • 2005

Published In

Volume / Issue

  • 59 /

Start / End Page

  • 43 - 67

PubMed ID

  • 15792496

Pubmed Central ID

  • 15792496

International Standard Serial Number (ISSN)

  • 0066-4227

Digital Object Identifier (DOI)

  • 10.1146/annurev.micro.59.030804.121255


  • eng

Conference Location

  • United States