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Effects of nicotine on brain responses to emotional pictures.

Publication ,  Journal Article
Gilbert, DG; Sugai, C; Zuo, Y; Eau Claire, N; McClernon, FJ; Rabinovich, NE; Markus, T; Asgaard, G; Radtke, R
Published in: Nicotine Tob Res
December 2004

Given that nicotine reduces negative affect, one would expect nicotine to have different effects on brain responses to emotionally negative stimuli than it does on responses to emotionally neutral or positive stimuli. However, no studies have assessed this possibility. The present study assessed the effects of nicotine patch versus placebo patch on brain event-related potential (ERP) responses to emotion-inducing negative, positive, and neutral color pictures in 16 smokers in a double-blind, counterbalanced, within-subjects design. The study included four experimental sessions. After overnight smoking deprivation (12 hr or more), active nicotine patches were applied to participants during one of the first two sessions and during one of the last two sessions. Placebo patches were applied during the other two sessions. Nicotine reduced frontal ERP processing voltage negativity (from 144-488 ms poststimulus onset) evoked by viewing emotionally negative pictures to a greater extent than it did when emotionally neutral pictures were viewed, whereas it had no effect on processing negativity evoked by positive pictures. Nicotine also enhanced P390 amplitudes evoked by emotionally negative pictures more than it did when emotionally neutral and positive pictures were viewed. Across picture types, nicotine (relative to placebo) reduced N300 amplitude (more at anterior and dorsal sites) and increased P390 amplitude. Overall, nicotine influenced ERPs to emotionally neutral and positive pictures less than it did to negative pictures.

Duke Scholars

Published In

Nicotine Tob Res

DOI

ISSN

1462-2203

Publication Date

December 2004

Volume

6

Issue

6

Start / End Page

985 / 996

Location

England

Related Subject Headings

  • Visual Perception
  • Public Health
  • Nicotine
  • Male
  • Humans
  • Ganglionic Stimulants
  • Female
  • Electroencephalography
  • Brain
  • Affect
 

Citation

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Gilbert, D. G., Sugai, C., Zuo, Y., Eau Claire, N., McClernon, F. J., Rabinovich, N. E., … Radtke, R. (2004). Effects of nicotine on brain responses to emotional pictures. Nicotine Tob Res, 6(6), 985–996. https://doi.org/10.1080/14622200412331324947
Gilbert, David G., Chihiro Sugai, Yantao Zuo, Noelle Eau Claire, F Joseph McClernon, Norka E. Rabinovich, Tiffanie Markus, Greg Asgaard, and Robert Radtke. “Effects of nicotine on brain responses to emotional pictures.Nicotine Tob Res 6, no. 6 (December 2004): 985–96. https://doi.org/10.1080/14622200412331324947.
Gilbert DG, Sugai C, Zuo Y, Eau Claire N, McClernon FJ, Rabinovich NE, et al. Effects of nicotine on brain responses to emotional pictures. Nicotine Tob Res. 2004 Dec;6(6):985–96.
Gilbert, David G., et al. “Effects of nicotine on brain responses to emotional pictures.Nicotine Tob Res, vol. 6, no. 6, Dec. 2004, pp. 985–96. Pubmed, doi:10.1080/14622200412331324947.
Gilbert DG, Sugai C, Zuo Y, Eau Claire N, McClernon FJ, Rabinovich NE, Markus T, Asgaard G, Radtke R. Effects of nicotine on brain responses to emotional pictures. Nicotine Tob Res. 2004 Dec;6(6):985–996.
Journal cover image

Published In

Nicotine Tob Res

DOI

ISSN

1462-2203

Publication Date

December 2004

Volume

6

Issue

6

Start / End Page

985 / 996

Location

England

Related Subject Headings

  • Visual Perception
  • Public Health
  • Nicotine
  • Male
  • Humans
  • Ganglionic Stimulants
  • Female
  • Electroencephalography
  • Brain
  • Affect