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Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell.

Publication ,  Journal Article
Pandol, SJ; Gukovskaya, A; Bahnson, TD; Dionne, VE
Published in: Ann N Y Acad Sci
March 23, 1994

Figure 1 summarizes our current concept of a signaling mechanism to explain agonist-induced Ca2+ entry in the pancreatic acinar cell. We propose that cGMP can modulate Ca2+ entry under conditions of internal Ca2+ store depletion and that the NO signaling system may be involved in coupling Ca2+ depletion to cGMP formation. The finding that Ca2+ entry after Ca2+ store depletion can occur with no elevation in [Ca2+]i37 raises the possibility that alternative signaling pathways may converge to stimulate cGMP formation or that additional messengers may activate plasmalemmal Ca2+ entry mechanisms in parallel.

Duke Scholars

Published In

Ann N Y Acad Sci

DOI

ISSN

0077-8923

Publication Date

March 23, 1994

Volume

713

Start / End Page

41 / 48

Location

United States

Related Subject Headings

  • Signal Transduction
  • Second Messenger Systems
  • Pancreas
  • Models, Biological
  • General Science & Technology
  • Cyclic GMP
  • Cholecystokinin
  • Calcium
  • Animals
  • Acetylcholine
 

Citation

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Pandol, S. J., Gukovskaya, A., Bahnson, T. D., & Dionne, V. E. (1994). Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell. Ann N Y Acad Sci, 713, 41–48. https://doi.org/10.1111/j.1749-6632.1994.tb44051.x
Pandol, S. J., A. Gukovskaya, T. D. Bahnson, and V. E. Dionne. “Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell.Ann N Y Acad Sci 713 (March 23, 1994): 41–48. https://doi.org/10.1111/j.1749-6632.1994.tb44051.x.
Pandol SJ, Gukovskaya A, Bahnson TD, Dionne VE. Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell. Ann N Y Acad Sci. 1994 Mar 23;713:41–8.
Pandol, S. J., et al. “Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell.Ann N Y Acad Sci, vol. 713, Mar. 1994, pp. 41–48. Pubmed, doi:10.1111/j.1749-6632.1994.tb44051.x.
Pandol SJ, Gukovskaya A, Bahnson TD, Dionne VE. Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell. Ann N Y Acad Sci. 1994 Mar 23;713:41–48.
Journal cover image

Published In

Ann N Y Acad Sci

DOI

ISSN

0077-8923

Publication Date

March 23, 1994

Volume

713

Start / End Page

41 / 48

Location

United States

Related Subject Headings

  • Signal Transduction
  • Second Messenger Systems
  • Pancreas
  • Models, Biological
  • General Science & Technology
  • Cyclic GMP
  • Cholecystokinin
  • Calcium
  • Animals
  • Acetylcholine