Cellular mechanisms mediating agonist-stimulated calcium influx in the pancreatic acinar cell.
Journal Article (Journal Article;Review)
Figure 1 summarizes our current concept of a signaling mechanism to explain agonist-induced Ca2+ entry in the pancreatic acinar cell. We propose that cGMP can modulate Ca2+ entry under conditions of internal Ca2+ store depletion and that the NO signaling system may be involved in coupling Ca2+ depletion to cGMP formation. The finding that Ca2+ entry after Ca2+ store depletion can occur with no elevation in [Ca2+]i37 raises the possibility that alternative signaling pathways may converge to stimulate cGMP formation or that additional messengers may activate plasmalemmal Ca2+ entry mechanisms in parallel.
Full Text
Duke Authors
Cited Authors
- Pandol, SJ; Gukovskaya, A; Bahnson, TD; Dionne, VE
Published Date
- March 23, 1994
Published In
Volume / Issue
- 713 /
Start / End Page
- 41 - 48
PubMed ID
- 8185204
International Standard Serial Number (ISSN)
- 0077-8923
Digital Object Identifier (DOI)
- 10.1111/j.1749-6632.1994.tb44051.x
Language
- eng
Conference Location
- United States