Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype.


Journal Article

Hippocampal sulcal cavities are usually considered incidental findings on brain MRI. In a group of 92 elderly volunteers, the authors graded the number and size of hippocampal sulcal cavities with brain MRI to obtain a cavity score. Cavity scores increased with age, and were higher in subjects carrying the APOE epsilon4 or epsilon2 alleles than in subjects with the epsilon3/3 genotype. Age-related morphologic changes in the hippocampus may be mediated by the APOE genotype.

Full Text

Duke Authors

Cited Authors

  • Barboriak, DP; Doraiswamy, PM; Krishnan, KR; Vidyarthi, S; Sylvester, J; Charles, HC

Published Date

  • June 13, 2000

Published In

Volume / Issue

  • 54 / 11

Start / End Page

  • 2150 - 2153

PubMed ID

  • 10851380

Pubmed Central ID

  • 10851380

International Standard Serial Number (ISSN)

  • 0028-3878

Digital Object Identifier (DOI)

  • 10.1212/wnl.54.11.2150


  • eng

Conference Location

  • United States