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MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex.

Publication ,  Journal Article
Kim, DM; Xanthakos, SA; Tupler, LA; Barboriak, DP; Charles, HC; MacFall, JR; Krishnan, KRR
Published in: Psychiatry Res
July 1, 2002

Signal intensity (SI) values of gray- and white-matter brain regions of interest (ROIs) were obtained from T(2)- and proton density-weighted magnetic resonance (MR) images of 58 normal subjects aged 22-82 years (31 females, 52.3+/-18.8 years; 27 males, 54.1+/-18.1 years). Sampled ROIs included the caudate, putamen, thalamus, orbitofrontal gyrus, gyrus rectus, uncus, frontal white matter, anterior and posterior corpus callosum, cranial-cervical junction fat, and retroorbital fat. Effects of age and sex on SI were examined using repeated-measures analysis of covariance. For both T(2)- and proton density-weighted acquisitions, a significant inverse relationship between age and SI was observed for the ratio of all summed gray-matter ROIs divided by summed white-matter ROIs. This relationship was additionally observed for ratios of both subcortical gray/white matter and cortical gray/white matter. Females compared with males had significantly lower cortical gray/white matter ratios on T(2)-weighted scans. Differences in SI were observed between cranial-cervical junction fat and retroorbital fat on both acquisitions, with females showing significantly higher values for cranial-cervical junction fat and males showing higher values for retroorbital fat. Implications for brain morphometry, the use of fat as a reference standard, and other issues in neuroimaging are discussed.

Duke Scholars

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

July 1, 2002

Volume

114

Issue

3

Start / End Page

149 / 161

Location

Ireland

Related Subject Headings

  • Sex Factors
  • Psychiatry
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Brain
  • Aged, 80 and over
  • Aged
 

Citation

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Kim, D. M., Xanthakos, S. A., Tupler, L. A., Barboriak, D. P., Charles, H. C., MacFall, J. R., & Krishnan, K. R. R. (2002). MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex. Psychiatry Res, 114(3), 149–161. https://doi.org/10.1016/s0925-4927(02)00024-0
Kim, Dennis M., Stavra A. Xanthakos, Larry A. Tupler, Daniel P. Barboriak, H Cecil Charles, James R. MacFall, and K Ranga Rama Krishnan. “MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex.Psychiatry Res 114, no. 3 (July 1, 2002): 149–61. https://doi.org/10.1016/s0925-4927(02)00024-0.
Kim DM, Xanthakos SA, Tupler LA, Barboriak DP, Charles HC, MacFall JR, et al. MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex. Psychiatry Res. 2002 Jul 1;114(3):149–61.
Kim, Dennis M., et al. “MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex.Psychiatry Res, vol. 114, no. 3, July 2002, pp. 149–61. Pubmed, doi:10.1016/s0925-4927(02)00024-0.
Kim DM, Xanthakos SA, Tupler LA, Barboriak DP, Charles HC, MacFall JR, Krishnan KRR. MR signal intensity of gray matter/white matter contrast and intracranial fat: effects of age and sex. Psychiatry Res. 2002 Jul 1;114(3):149–161.
Journal cover image

Published In

Psychiatry Res

DOI

ISSN

0165-1781

Publication Date

July 1, 2002

Volume

114

Issue

3

Start / End Page

149 / 161

Location

Ireland

Related Subject Headings

  • Sex Factors
  • Psychiatry
  • Middle Aged
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Female
  • Brain
  • Aged, 80 and over
  • Aged