Infant cerebral ventricle volume: a comparison of 3-D ultrasound and magnetic resonance imaging.

Journal Article

Enlargement of the cerebral lateral ventricles is observed in several neuropsychiatric disorders with origins in early brain development. Lateral ventricle size is also predictive of poor neurodevelopmental outcome in premature infants. Three-dimensional (3-D) ultrasound (US) offers an improved methodology for the study of lateral ventricle volume in neonates and infants. To assess the validity of ventricle volume measures obtained with 3-D US, we compared the volumes obtained by 3-D US with magnetic resonance imaging (MRI) in seven infants. Ventricle volumes were determined using a computer-assisted image analysis program, IRIS. There was excellent correlation between ventricle volumes obtained with 3-D US and those obtained with MRI (intraclass correlation coefficient 0.92, F = 23.28, p = 0.00027), indicating that 3-D US provides valid measures of overall lateral ventricle volume compared to the "gold standard" of MRI. 3-D US can provide an economical and practical means of studying lateral ventricle volume in neonates, a neurostructural marker of abnormal brain development.

Full Text

Duke Authors

Cited Authors

  • Gilmore, JH; Gerig, G; Specter, B; Charles, HC; Wilber, JS; Hertzberg, BS; Kliewer, MA

Published Date

  • August 2001

Published In

Volume / Issue

  • 27 / 8

Start / End Page

  • 1143 - 1146

PubMed ID

  • 11527602

Pubmed Central ID

  • 11527602

International Standard Serial Number (ISSN)

  • 0301-5629

Digital Object Identifier (DOI)

  • 10.1016/s0301-5629(01)00400-8


  • eng

Conference Location

  • England