Methodological standardization for a multi-institutional in vivo trial of localized 31P MR spectroscopy in human cancer research. In vitro and normal volunteer studies.


Journal Article (Review)

A multi-institutional group has been created to demonstrate the utility of in vivo 31P magnetic resonance spectroscopy (31P-MRS) to study human cancers in vivo. This review is concerned with the novel problems concerning quality control in this large multinational trial of 31P MRS. Our results show that the careful and systematic performance of the quality control tests depicted here (standardized dual 1H/31P tuned radiofrequency probe, quality control procedures, routine use of 1H irradiation while acquiring 31P MR signals) has ensured comparable results between the different institutions. In studies made in vitro, the root-mean-square error was 3.6 %, and in muscle of healthy volunteers in vivo the coefficients of variance for the ratios phosphocreatine/nucleotide-triphosphates, phosphocreatine/noise and nucleotide-triphosphate/noise were 12.2, 7.0 and 10.8 %, respectively. The standardization of the acquisition protocol for in vivo-localized 31P MR spectroscopy across the different institutions has resulted in comparable in vivo data, decreasing the possible problems related to a research study carried out under a multi-institutional setting.

Full Text

Duke Authors

Cited Authors

  • Arias-Mendoza, F; Zakian, K; Schwartz, A; Howe, FA; Koutcher, JA; Leach, MO; Griffiths, JR; Heerschap, A; Glickson, JD; Nelson, SJ; Evelhoch, JL; Charles, HC; Brown, TR; Cooperative Group on MRS Applications in Cancer,

Published Date

  • October 2004

Published In

Volume / Issue

  • 17 / 6

Start / End Page

  • 382 - 391

PubMed ID

  • 15386624

Pubmed Central ID

  • 15386624

International Standard Serial Number (ISSN)

  • 0952-3480

Digital Object Identifier (DOI)

  • 10.1002/nbm.915


  • eng

Conference Location

  • England