Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia.

Journal Article (Journal Article)

Glutamate decarboxylase (GAD) activity was measured in the nuclei of the basal ganglia in patients with neuroleptic-induced tardive dyskinesia (TD) and controls matched for age and premortem state. In five TD patients, who all had a sudden death, a significant decrease in GAD activity was found in the subthalamic nucleus (STN). The lowered GAD activity in the STN may represent a biochemical substrate for neuroleptic-induced TD.

Full Text

Duke Authors

Cited Authors

  • Andersson, U; Häggström, JE; Levin, ED; Bondesson, U; Valverius, M; Gunne, LM

Published Date

  • 1989

Published In

Volume / Issue

  • 4 / 1

Start / End Page

  • 37 - 46

PubMed ID

  • 2927401

International Standard Serial Number (ISSN)

  • 0885-3185

Digital Object Identifier (DOI)

  • 10.1002/mds.870040107


  • eng

Conference Location

  • United States