Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia.
Journal Article (Journal Article)
Glutamate decarboxylase (GAD) activity was measured in the nuclei of the basal ganglia in patients with neuroleptic-induced tardive dyskinesia (TD) and controls matched for age and premortem state. In five TD patients, who all had a sudden death, a significant decrease in GAD activity was found in the subthalamic nucleus (STN). The lowered GAD activity in the STN may represent a biochemical substrate for neuroleptic-induced TD.
- Andersson, U; Häggström, JE; Levin, ED; Bondesson, U; Valverius, M; Gunne, LM
Volume / Issue
- 4 / 1
Start / End Page
- 37 - 46
International Standard Serial Number (ISSN)
Digital Object Identifier (DOI)
- United States