Reduced glutamate decarboxylase activity in the subthalamic nucleus in patients with tardive dyskinesia.
Glutamate decarboxylase (GAD) activity was measured in the nuclei of the basal ganglia in patients with neuroleptic-induced tardive dyskinesia (TD) and controls matched for age and premortem state. In five TD patients, who all had a sudden death, a significant decrease in GAD activity was found in the subthalamic nucleus (STN). The lowered GAD activity in the STN may represent a biochemical substrate for neuroleptic-induced TD.
Andersson, U; Häggström, JE; Levin, ED; Bondesson, U; Valverius, M; Gunne, LM
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